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重组人Activin receptor type-2B/ACVR2B Protein(C-Fc-6His)

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产品名称: 重组人Activin receptor type-2B/ACVR2B Protein(C-Fc-6His)
产品型号: PN100016-10ug
产品展商: PERFEMIKER
产品价格: 400.00 元
会员价格: 0.00 元
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简单介绍

重组人Activin receptor type-2B/ACVR2B Protein(C-Fc-6His) 货号:PN100016 规格:10ug; 标签:C-Fc-6His; 来源:Human; 表达宿主:Human cells


重组人Activin receptor type-2B/ACVR2B Protein(C-Fc-6His)  的详细介绍

名称:重组人Activin receptor type-2B/ACVR2B Protein(C-Fc-6His);


产品说明(Description)
Recombinant Human Activin Receptor Type 2B is produced by our Mammalian expression system and the target gene encoding Ser19-Thr134 is expressed with a Fc, 6His tag at the C-terminus. 
Accession #: Q13705
Known as: Activin Receptor Type-2B; Activin Receptor Type IIB; ACTR-IIB; ACVR2B

制剂(Formulation)
Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

质量控制(Quality Control) 
Bioactivity*   Measured by its ability to bind Human Activin A in functional ELISA.
The ED50 for this effect is less than 100 ng/ml
Purity: Greater than 95% as determined by reducing SDS-PAGE.    
Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

复溶(Reconstitution)
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.    

保存(Storage)
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.    

背景(Background)
Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity, and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB, also known as ActRIIB, is a type II receptor containing an extracellular domain (ECD), a transmembrane segment, and a cytoplasmic region that includes the kinase domain. ActRIIB is a receptor for activin A, activin B and inhibin A. Multiple ActRIIB isoforms can also be generated, which bind activin isoforms with different affinities.

电泳(SDS-PAGE)

FOR RESEARCH USE ONLY