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重组小鼠Activin Receptor-like Kinase 1/ALK-1/ACVRL1Protein(C-Fc)

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产品名称: 重组小鼠Activin Receptor-like Kinase 1/ALK-1/ACVRL1Protein(C-Fc)
产品型号: PN100017-50ug
产品展商: PERFEMIKER
产品价格: 720.00 元
会员价格: 0.00 元
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简单介绍

重组小鼠Activin Receptor-like Kinase 1/ALK-1/ACVRL1Protein(C-Fc) 货号:PN100017 规格:50ug; 标签:C-Fc; 来源:Mouse; 表达宿主:Human Cells


重组小鼠Activin Receptor-like Kinase 1/ALK-1/ACVRL1Protein(C-Fc)  的详细介绍

名称:重组小鼠Activin Receptor-like Kinase 1/ALK-1/ACVRL1Protein(C-Fc);


产品说明(Description)
Recombinant Mouse Activin Receptor-like Kinase 1 is produced by our Mammalian expression system and the target gene encoding Asp23-Pro119 is expressed with a Fc tag at the C-terminus. 
Accession #: Q61288
Known as: Serine/threonine-protein kinase receptor R3; SKR3; Activin receptor-like kinase 1; ALK-1; TGF-B superfamily receptor type I; TSR-I; ACVRL1; activin A receptor type II-like 1; activin A receptor

制剂(Formulation)
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

质量控制(Quality Control) 
Purity: Greater than 95% as determined by reducing SDS-PAGE.    
Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

复溶(Reconstitution)
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.    

保存(Storage)
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.    

背景(Background)
Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-β superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis, wound healing, and tumor growth. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. ALK-1 is mainly expressed in endothelial cells regulating proliferation and migration in vitro and angiogenesis in vivo. Mutations in ALK-1 as well as in endoglin are associated with hereditary hemorrhagic telangiectasia (HHT), suggesting ALK-1 plays a critical role for in the control of blood vessel development or repair.

电泳(SDS-PAGE)

FOR RESEARCH USE ONLY