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重组小鼠BMPR1A/ALK-3/BMPR?IAProtein(C-Fc-6His)

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产品名称: 重组小鼠BMPR1A/ALK-3/BMPR?IAProtein(C-Fc-6His)
产品型号: PN100044-10ug
产品展商: PERFEMIKER
产品价格: 400.00 元
会员价格: 0.00 元
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简单介绍

重组小鼠BMPR1A/ALK-3/BMPR?IAProtein(C-Fc-6His) 货号:PN100044 规格:10ug; 标签:C-Fc-6His; 来源:Mouse; 表达宿主:Human cells


重组小鼠BMPR1A/ALK-3/BMPR?IAProtein(C-Fc-6His)  的详细介绍

名称:重组小鼠BMPR1A/ALK-3/BMPR?IAProtein(C-Fc-6His);


产品说明(Description)
Recombinant Mouse Bone Morphogenetic Protein Receptor Type IA/Activin Receptor-like Kinase 3 is produced by our Mammalian expression system and the target gene encoding Gln24-Arg152 is expressed with a Fc, 6His tag at the C-terminus. 
Accession #: P36895
Known as: ALK-3;Bone morphogenetic protein receptor type-1A;BMP type-1A receptor;BMPR-1A;Activin receptor-like kinase 3;BMP-2/BMP-4 receptor;Serine/threonine-protein kinase receptor R5;SKR5;CD292;;Acvrlk3

制剂(Formulation)
Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

质量控制(Quality Control) 
Purity: Greater than 95% as determined by reducing SDS-PAGE.    
Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

复溶(Reconstitution)
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.    

保存(Storage)
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.    

背景(Background)
ALK-3 is a type I receptor for bone morphogenetic proteins (BMPs) which belong to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. The BMP receptors consists of the type I receptors BMPR1A and BMPR1B and the type I I receptor BMPR2. Seven known type I serine/threonine kinases and five mammalian type II serine/threonine kinase receptors function in TGF-beta superfamily signal transduction. The downstream molecules of the type I BMP receptors include the Smad (Smad1, 5 and 8) proteins that are phosphorylated in a ligand-dependent manner, and relay the BMP signal from the receptors to target genes in the nucleus. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. ALK-3 contains a GS domain and a protein kinase domain. ALK-3 is widely expressed. Defects in BMPR1A gene are a cause of a significant proportion of cases of Juvenile polyposis syndrome (JPS).

电泳(SDS-PAGE)

FOR RESEARCH USE ONLY