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重组人Alkaline Phosphatase/ALPLProtein(C-6His)

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产品名称: 重组人Alkaline Phosphatase/ALPLProtein(C-6His)
产品型号: PN100045-10ug
产品展商: PERFEMIKER
产品价格: 1200.00 元
会员价格: 0.00 元
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简单介绍

重组人Alkaline Phosphatase/ALPLProtein(C-6His) 货号:PN100045 规格:10ug; 标签:C-6His; 来源:Human; 表达宿主:Human cells


重组人Alkaline Phosphatase/ALPLProtein(C-6His)  的详细介绍

名称:重组人Alkaline Phosphatase/ALPLProtein(C-6His);


产品说明(Description)
Recombinant Human Alkaline Phosphatase, Tissue-Nonspecific Isozyme is produced by our Mammalian expression system and the target gene encoding Leu18-Ser502 is expressed with a 6His tag at the C-terminus. 
Accession #: P05186
Known as: Alkaline Phosphatase; Tissue-Nonspecific Isozyme; AP-TNAP; TNSALP; Alkaline Phosphatase Liver/Bone/Kidney Isozyme; ALPL

制剂(Formulation)
Supplied as a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, 2mM MgSO4, 0.1mM ZnCl2, pH 7.5.

质量控制(Quality Control) 
Purity: Greater than 95% as determined by reducing SDS-PAGE.    
Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

复溶(Reconstitution)

保存(Storage)
Store at < -20°C, stable for 6 months after receipt.Please minimize freeze-thaw cycles.   

背景(Background)
Alkaline Phosphatase, Tissue-Nonspecific Isozyme (ALPL) is a cell membrane protein which belongs to the alkaline phosphatase family. There are at least four distinct but related alkaline phosphatases in humans: intestinal AP (IAP), placental AP(PLAP), germ cell AP (GCAP) and their genes are clustered on chromosome 2, tissue-nonspecific isozyme (TNAP) which gene is located on chromosome 1. Alkaline phosphatases (APs) are dimeric enzymes, it catalyze the hydrolysis of phosphomonoesters with release of inorganic phosphate. The native ALPL is a glycosylated homodimer attached to the membrane through a GPI-anchor. This isozyme may play a role in skeletal mineralization. Mutations in ALPL gene have been linked directly to different forms of hypophosphatasia,characterized by poorly mineralized cartilage and bones, and this disorder can vary depending on the specific mutation since this determines age of onset and severity of symptoms.

电泳(SDS-PAGE)

FOR RESEARCH USE ONLY