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重组人Angiopoietin-like Protein 8/Betatrophin /C19orf81Protein(N-Fc)

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产品名称: 重组人Angiopoietin-like Protein 8/Betatrophin /C19orf81Protein(N-Fc)
产品型号: PN100067-10ug
产品展商: PERFEMIKER
产品价格: 1200.00 元
会员价格: 0.00 元
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简单介绍

重组人Angiopoietin-like Protein 8/Betatrophin /C19orf81Protein(N-Fc) 货号:PN100067 规格:10ug; 标签:N-Fc; 来源:Human; 表达宿主:Human cells


重组人Angiopoietin-like Protein 8/Betatrophin /C19orf81Protein(N-Fc)  的详细介绍

名称:重组人Angiopoietin-like Protein 8/Betatrophin /C19orf81Protein(N-Fc);


产品说明(Description)
Recombinant Human Angiopoietin-like protein 8 is produced by our Mammalian expression system and the target gene encoding Ala22-Ala198 is expressed with a Fc tag at the N-terminus. 
Accession #: Q6UXH0
Known as: Betatrophin;Angiopoietin-like protein 8;Lipasin;Angptl8

制剂(Formulation)
Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

质量控制(Quality Control) 
Purity: Greater than 95% as determined by reducing SDS-PAGE.    
Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

复溶(Reconstitution)
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.    

保存(Storage)
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.    

背景(Background)
The protein specifically promotes pancreatic beta cell proliferation and beta cell mass expansion, thereby improving glucose tolerance. It promotes pancreatic beta cell proliferation without insulin resistance. Also it acts as a blood lipid regulator by regulating serum triglyceride levels and possibly by promoting ANGPTL3 cleavage. It interacts with ANGPTL3. It predominantly expressed in liver and also expressed in adipose tissues. The ability of the protein to induce pancreatic beta cell proliferation is promising in diabetes therapy. Betatrophin treatment could supply or replace insulin injections by increasing the number of insulin-producing cells in diabetes.

电泳(SDS-PAGE)

FOR RESEARCH USE ONLY