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重组人APE/APE1/APEXProtein(None)

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产品名称: 重组人APE/APE1/APEXProtein(None)
产品型号: PN100083-10ug
产品展商: PERFEMIKER
产品价格: 840.00 元
会员价格: 0.00 元
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简单介绍

重组人APE/APE1/APEXProtein(None) 货号:PN100083 规格:10ug; 标签:None; 来源:Human; 表达宿主:E.coli


重组人APE/APE1/APEXProtein(None)  的详细介绍

名称:重组人APE/APE1/APEXProtein(None);


产品说明(Description)
Recombinant Human Apurinic-Apyrimidinic Endonuclease 1 is produced by our E.coli expression system and the target gene encoding Pro2-Leu318 is expressed. 
Accession #: P27695
Known as: DNA-(Apurinic or Apyrimidinic Site) Lyase; APEX Nuclease; APEN; Apurinic-Apyrimidinic Endonuclease 1; AP Endonuclease 1; APE-1REF-1; Redox Factor-1; APEX1; APE; APE1; APEX; APX; HAP1; REF1

制剂(Formulation)
Supplied as a 0.2 μm filtered solution of 10mM HEPES, 100mM KCl, 50% Glycerol, pH 7.4.

质量控制(Quality Control) 
Purity: Greater than 95% as determined by reducing SDS-PAGE.    
Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

复溶(Reconstitution)

保存(Storage)
Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.   

背景(Background)
Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.

电泳(SDS-PAGE)

FOR RESEARCH USE ONLY