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重组人ARC/NOL3 Protein(None)

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产品名称: 重组人ARC/NOL3 Protein(None)
产品型号: PN100099-10ug
产品展商: PERFEMIKER
产品价格: 840.00 元
会员价格: 0.00 元
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简单介绍

重组人ARC/NOL3 Protein(None) 货号:PN100099 规格:10ug; 标签:None; 来源:Human; 表达宿主:E.coli


重组人ARC/NOL3 Protein(None)  的详细介绍

名称:重组人ARC/NOL3 Protein(None);


产品说明(Description)
Recombinant Human Nucleolar Protein 3 is produced by our E.coli expression system and the target gene encoding Met1-Ser208 is expressed. 
Accession #: O60936
Known as: Nucleolar Protein 3; Apoptosis Repressor With CARD; Muscle-Enriched Cytoplasmic Protein; Myp; Nucleolar Protein of 30 kDa; Nop30

制剂(Formulation)
Supplied as a 0.2 μm filtered solution of 25mM TrisHCl, 1mM DTT, 1mM EDTA, 2mM β-ME, 20% Glycerol, pH 7.5.

质量控制(Quality Control) 
Purity: Greater than 90% as determined by reducing SDS-PAGE.    
Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

复溶(Reconstitution)

保存(Storage)
Store at < -20°C, stable for 6 months after receipt.Please minimize freeze-thaw cycles.   

背景(Background)
Nucleolar protein 3 is encoded by NOL3 gene. Multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death. It inhibits extrinsic apoptotic pathways through two different ways. Firstly, it by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly. Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation. It has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53.

电泳(SDS-PAGE)

FOR RESEARCH USE ONLY