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重组人ATP-binding cassette sub-family B member 5/ABCB5Protein(N-Trx)

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产品名称: 重组人ATP-binding cassette sub-family B member 5/ABCB5Protein(N-Trx)
产品型号: PN100119-50ug
产品展商: PERFEMIKER
产品价格: 3520.00 元
会员价格: 0.00 元
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简单介绍

重组人ATP-binding cassette sub-family B member 5/ABCB5Protein(N-Trx) 货号:PN100119 规格:50ug; 标签:N-Trx; 来源:Human; 表达宿主:E.coli


重组人ATP-binding cassette sub-family B member 5/ABCB5Protein(N-Trx)  的详细介绍

名称:重组人ATP-binding cassette sub-family B member 5/ABCB5Protein(N-Trx);


产品说明(Description)
Recombinant Human ATP-binding cassette sub-family B member 5 is produced by our E.coli expression system and the target gene encoding Ile141-Val247 is expressed with a Trx tag at the N-terminus. 
Accession #: Q2M3G0
Known as: ATP-binding cassette sub-family B member 5; P-glycoprotein ABCB5; ABCB5 P-gp; ABCB5;

制剂(Formulation)
Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.

质量控制(Quality Control) 
Purity: Greater than 85% as determined by reducing SDS-PAGE.    
Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

复溶(Reconstitution)
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.    

保存(Storage)
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.    

背景(Background)
ATP-binding cassette sub-family B member 5(ABCB5) is a plasma membrane-spanning protein. ABCB5 is principally expressed in physiological skin and human malignant melanoma. ABCB5 has been suggested to regulate skin progenitor cell fusion and mediate chemotherapeutic drug resistance in stem-like tumor cell subpopulations in human malignant melanoma. It is commonly over-expressed on circulating melanoma tumour cells. Furthermore, the ABCB5+ melanoma- initiating cells were demonstrated to express FLT1 (VEGFR1) receptor tyrosine kinase which was functionally required for efficient xenograft tumor formation, as demonstrated by shRNA knockdown experiments.

电泳(SDS-PAGE)

FOR RESEARCH USE ONLY