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重组人Azurocidin/CAP37/HBPProtein(C-6His)

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产品名称: 重组人Azurocidin/CAP37/HBPProtein(C-6His)
产品型号: PN100120-10ug
产品展商: PERFEMIKER
产品价格: 640.00 元
会员价格: 0.00 元
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简单介绍

重组人Azurocidin/CAP37/HBPProtein(C-6His) 货号:PN100120 规格:10ug; 标签:C-6His; 来源:Human; 表达宿主:Human cells


重组人Azurocidin/CAP37/HBPProtein(C-6His)  的详细介绍

名称:重组人Azurocidin/CAP37/HBPProtein(C-6His);


产品说明(Description)
Recombinant Human Cationic Antimicrobial Protein-37 is produced by our Mammalian expression system and the target gene encoding Ile27-Pro250 is expressed with a 6His tag at the C-terminus. 
Accession #: P20160
Known as: Azurocidin; Cationic Antimicrobial Protein CAP37; Heparin-Binding Protein; HBP; AZU1

制剂(Formulation)
Lyophilized from a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, pH 7.5.

质量控制(Quality Control) 
Purity: Greater than 95% as determined by reducing SDS-PAGE.    
Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

复溶(Reconstitution)
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.    

保存(Storage)
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.    

背景(Background)
Azurocidin is an Azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. The Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. Azurocidin is a member of the serine protease family that includes Cathepsin G, Neutrophil Elastase (NE), and Proteinase 3 (PR3), however, Azurocidin is not a serine proteinase since the active site serine and histidine residues are replaced. Human Azurocidin together with NE and PR3 are expressed coordinately and are packaged together into azurophil granules during neutrophil differentiation. Azurocidin has been identified as a modulator of endothelial permeability and an important multifunctional inflammatory mediator. Neutrophils arriving first at sites of inflammation release Azurocidin which acts in a paracrine fashion on endothelial cells causing the development of intercellular gaps and allowing leukocyte extravasation. Azurocidin thus be regarded as a reasonable therapeutic target for a variety of inflammatory disease conditions.

电泳(SDS-PAGE)

FOR RESEARCH USE ONLY