名称:重组人Cathepsin B/CTSBProtein(C-6His);
产品说明(Description) Recombinant Human Cathepsin B is produced by our Mammalian expression system and the target gene encoding Arg18-Ile339 is expressed with a 6His tag at the C-terminus. Accession #: P07858 Known as: Cathepsin B; APP Secretase; APPS; Cathepsin B1; CTSB; CPSB 制剂(Formulation) Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0. 质量控制(Quality Control) Bioactivity* Measured by its ability to cleave the fluorogenic peptide substrate Z-LR-AMC Specific Activity is greater than 2500 pmol/min/ug Purity: Greater than 95% as determined by reducing SDS-PAGE. Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test. 复溶(Reconstitution) 保存(Storage) Store at < -20°C, stable for 6 months after receipt.Please minimize freeze-thaw cycles. 背景(Background) Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. At least five transcript variants encoding the same protein have been found for this gene. Cystatin-B / CSTB is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. Cystatin-B / CSTB is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Cystatin-B / CSTB is also thought to play a role in protecting against the proteases leaking from lysosomes 电泳(SDS-PAGE) FOR RESEARCH USE ONLY