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重组人Cathepsin B/CTSBProtein(C-6His)

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产品名称: 重组人Cathepsin B/CTSBProtein(C-6His)
产品型号: PN100253-50ug
产品展商: PERFEMIKER
产品价格: 3520.00 元
会员价格: 0.00 元
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简单介绍

重组人Cathepsin B/CTSBProtein(C-6His) 货号:PN100253 规格:50ug; 标签:C-6His; 来源:Human; 表达宿主:Human cells


重组人Cathepsin B/CTSBProtein(C-6His)  的详细介绍

名称:重组人Cathepsin B/CTSBProtein(C-6His);


产品说明(Description)
Recombinant Human Cathepsin B is produced by our Mammalian expression system and the target gene encoding Arg18-Ile339 is expressed with a 6His tag at the C-terminus. 
Accession #: P07858
Known as: Cathepsin B; APP Secretase; APPS; Cathepsin B1; CTSB; CPSB

制剂(Formulation)
Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.

质量控制(Quality Control) 
Bioactivity*   Measured by its ability to cleave the fluorogenic peptide substrate Z-LR-AMC
Specific Activity is greater than 2500 pmol/min/ug
Purity: Greater than 95% as determined by reducing SDS-PAGE.    
Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

复溶(Reconstitution)

保存(Storage)
Store at < -20°C, stable for 6 months after receipt.Please minimize freeze-thaw cycles.   

背景(Background)
Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. At least five transcript variants encoding the same protein have been found for this gene. Cystatin-B / CSTB is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. Cystatin-B / CSTB is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Cystatin-B / CSTB is also thought to play a role in protecting against the proteases leaking from lysosomes

电泳(SDS-PAGE)

FOR RESEARCH USE ONLY