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重组人MMP-14

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产品名称: 重组人MMP-14
产品型号: PP1002136-500μg
产品展商: PERFEMIKER
产品价格: 22360.00 元
会员价格: 0.00 元
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简单介绍

名称:重组人MMP-14 货号:PP1002136 规格:500μg


重组人MMP-14  的详细介绍

名称:重组人MMP-14

Synonyms:MMP-X1, MT-MMP 1, MT1-MMP

Accession:P50281

GeneID:4323

Source:Escherichia coli.

Molecular Weight:Approximately 29.6 kDa, a single non-glycosylated polypeptide chain containing 264 amino acids.

AA Sequence:ALASLGSAQS SSFSPEAWLQ QYGYLPPGDL RTHTQRSPQS LSAAIAAMQK FYGLQVTGKA DADTMKAMRR PRCGVPDKFG AEIKANVRRK RYAIQGLKWQ HNEITFCIQN YTPKVGEYAT YEAIRKAFRV WESATPLRFR EVPYAYIREG HEKQADIMIF FAEGFHGDST PFDGEGGFLA HAYFPGPNIG GDTHFDSAEP WTVRNEDLNG NDIFLVAVHE LGHALGLEHS SDPSAIMAPF YQWMDTENFV LPDDDRRGIQ QLYG

Purity:> 95 % by SDS-PAGE and HPLC analyses.

Biological Activity:Test in Process.

Physical Appearance:Sterile colorless liquid.

Formulation:Supplied as a 0.2 μm filtered solution in 20 mM Tris-HCl, pH 7.4, 300 mM NaCl, 3 mM CaCl2,
10 μM ZnCl2, with 30 % glycerol.

Endotoxin:Less than 1 EU/µg of rHuMMP-14 as determined by LAL method.

Stability & Storage:Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 6 months from date of receipt, -20 to -70 °C as supplied.
- 3 months, -20 to -70 °C under sterile conditions after opening.

Background:As the first member of membrane type (MT) MMPs, MMP-14, also known as MT1-MMP, plays an important role in extracellular matrix (ECM) remodeling by being able to degrade type I collagen, activate pro-MMP-2 and process cell adhesion molecules such as CD44 and integrin alpha V. MMP-14 is therefore a key enzyme in many physiological and pathological processes such as angiogenesis and tumor invasion. Structurally, MMP-14 consists of the following domains: a pro domain containing the furin cleavage site, a catalytic domain containing the zinc-binding site, a hinge region, a hemopexin-like domain, a transmembrane domain, and a cytoplamasic tail. Recombinant Human MMP-14 consists of the pro and catalytic domains, which can be activated by treatment with furin as described in Activity Assay Protocol.