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重组人CT-1

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产品名称: 重组人CT-1
产品型号: PP1002182-250μg
产品展商: PERFEMIKER
产品价格: 17200.00 元
会员价格: 0.00 元
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简单介绍

名称:重组人CT-1 货号:PP1002182 规格:250μg


重组人CT-1  的详细介绍

名称:重组人CT-1

Accession:Q16619

GeneID:1489

Source:Escherichia coli.

Molecular Weight:Approximately 21.2 kDa, a single non-glycosylated polypeptide chain containing 201 amino acids.

AA Sequence:MSRREGSLED PQTDSSVSLL PHLEAKIRQT HSLAHLLTKY AEQLLQEYVQ LQGDPFGLPS FSPPRLPVAG LSAPAPSHAG LPVHERLRLD AAALAALPPL LDAVCRRQAE LNPRAPRLLR RLEDAARQAR ALGAAVEALL AALGAANRGP RAEPPAATAS AASATGVFPA KVLGLRVCGL YREWLSRTEG DLGQLLPGGS A

Purity:> 95 % by SDS-PAGE and HPLC analyses.

Biological Activity:Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 1.0 ng/ml, corresponding to a specific activity of > 1.0× 106 IU/mg.

Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation:Lyophilized from a 0.2 µm filtered concentrated solution in 30 % Acetonitrile and 0.1 % TFA.

Endotoxin:Less than 0.1 EU/µg of rHuCT-1 as determined by LAL method.

Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 4 mM HCl to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.

Stability & Storage:Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Background:Cardiotrophin-1 (CT-1) is a member of the cytokine family which also includes IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF)[Pennica, 1996 #1320]. CT-1 is a pleiotropic cytokine which is expressed in various tissues including the ***** heart, skeletal muscle, ovary, colon, prostate and fetal lung. Studies showed CT-1 which induces cardiac myocyte hypertrophy in vitro can bind to and activate the ILST/gp130 receptor. Human CT-1 encodes a 201 amino acid (a.a.) residue protein that lacks a hydrophobic signal peptide and it shares 78 % a.a. and 80 % a.a. sequence identity with murine and rat CT-1.