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重组人ACE-2Protein(C-6His)

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产品名称: 重组人ACE-2Protein(C-6His)
产品型号: PN100009-10ug
产品展商: PERFEMIKER
产品价格: 1200.00 元
会员价格: 0.00 元
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简单介绍

重组人ACE-2Protein(C-6His) 货号:PN100009 规格:10ug; 标签:C-6His; 来源:Human; 表达宿主:Human cells


重组人ACE-2Protein(C-6His)  的详细介绍

名称:重组人ACE-2Protein(C-6His);


产品说明(Description)
Recombinant Human Angiotensin-Converting Enzyme 2 is produced by our Mammalian expression system and the target gene encoding Gln18-Ser740 is expressed with a 6His tag at the C-terminus. 

Accession #: Q9BYF1

Known as: Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2


制剂(Formulation)
Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, 0.1mM ZnCl2, 10% Glycerol, pH 7.5.

质量控制(Quality Control) 
Bioactivity*   Measured by its ability to cleave a fluorogenic peptide substrate, Mca-YVADAPK(Dnp)-OH.
Specific Activity is greater than 500 pmol/min/μg.
Purity: Greater than 95% as determined by reducing SDS-PAGE.    
Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

复溶(Reconstitution)

保存(Storage)
Store at < -20°C, stable for 6 months after receipt.Please minimize freeze-thaw cycles.   

背景(Background)
Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.

电泳(SDS-PAGE)

FOR RESEARCH USE ONLY