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重组人Apoptosis Regulator Bcl-2Protein(C-6His)

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产品名称: 重组人Apoptosis Regulator Bcl-2Protein(C-6His)
产品型号: PN100097-10ug
产品展商: PERFEMIKER
产品价格: 760.00 元
会员价格: 0.00 元
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简单介绍

重组人Apoptosis Regulator Bcl-2Protein(C-6His) 货号:PN100097 规格:10ug; 标签:C-6His; 来源:Human; 表达宿主:E.coli


重组人Apoptosis Regulator Bcl-2Protein(C-6His)  的详细介绍

名称:重组人Apoptosis Regulator Bcl-2Protein(C-6His);



产品说明(Description)
Recombinant Human Apoptosis Regulator Bcl-2 is produced by our E.coli expression system and the target gene encoding Met1-Asp211 is expressed with a 6His tag at the C-terminus. 
Accession #: P10415
Known as: Apoptosis regulator Bcl-2; BCL2

制剂(Formulation)
Supplied as a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, 10%Glycerol, pH8.0.

质量控制(Quality Control) 
Purity: Greater than 95% as determined by reducing SDS-PAGE.    
Endotoxin: Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

复溶(Reconstitution)

保存(Storage)
Store at < -20°C, stable for 6 months after receipt.Please minimize freeze-thaw cycles.   

背景(Background)
Bcl-2 is a member of a family of proteins that regulates outer mitochondrial membrane permeability. Bcl-2 is an antiapoptotic member that prevents release of cytochrome c from the mitochondria intermembrane space into the cytosol. Bcl-2 is present on the outer mitochondrial membrane and is also found on other membranes in some cell types. BCL-2 is localized to the outer membrane of mitochondria,where it plays an important role in promoting cellular survival and inhibiting the actions of pro-apoptotic proteins. The pro-apoptotic proteins in the BCL-2 family, including Bax and Bak, normally act on the mitochondrial membrane to promote permeabilization and release of cytochrome C and ROS, that are important signals in the apotosis cascade. These pro-apoptotic proteins are in turn activated by BH3-only proteins, and are inhibited by the function of BCL-2 and its relative BCL-Xl.

电泳(SDS-PAGE)

FOR RESEARCH USE ONLY