名称：重组人CyP-D
Synonyms：PPIF, Cyclophilin F, CyP-M, Rotamase F
Accession：P30405
GeneID：10105
Unigene：Hs.381072
Source：Escherichia coli.
Molecular Weight：Approximately 18.9 kDa, a single non-glycosylated polypeptide chain containing 178 amino acids.
AA Sequence：CSKGSGDPSS SSSSGNPLVY LDVDANGKPL GRVVLELKAD VVPKTAENFR ALCTGEKGFG YKGSTFHRVI PSFMCQAGDF TNHNGTGGKS IYGSRFPDEN FTLKHVGPGV LSMANAGPNT NGSQFFICTI KTDWLDGKHV VFGHVKEGMD VVKKIESFGS KSGRTSKKIV ITDCGQLS
Purity：> 95 % by SDS-PAGE and HPLC analyses.
Biological Activity：Data Not Available.
Physical Appearance：Sterile colorless liquid.
Formulation：Supplied as a 0.2 μm filtered solution in PBS, pH7.4, with 1 mM DTT, 10 % glycerol.
Endotoxin：Less than 0.1 EU/μg of rHuCyP-D as determined by LAL method.
Stability & Storage：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - 6 months from date of receipt, -20 to -70 °C as supplied. - 3 months, -20 to -70 °C under sterile conditions after opening.
Background：CyP-D is a part of the peptidyl-prolyl cis-trans isomerase (PPIase) family. CyP-D accelerates the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. CyP-D is key component of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death.